Ferrous fumarate + folic acid

Anaemia other than those due to Fe deficiency, megaloblastic anaemia due to vitamin B₁₂ deficiency, paroxysmal nocturnal haemoglobinuria, haemosiderosis, haemochromatosis, haemoglobinopathies, inflammatory bowel disease including regional enteritis, ulcerative colitis, intestinal strictures, and diverticulae; active peptic ulcer. Patients requiring repeated blood transfusion. Concomitant use with parenteral Fe.

Patient with folate-dependent tumours, erythropoietic protoporphyria, treated or controlled peptic ulceration. Not indicated for the prevention of anaemia in children, men, and non-pregnant women. Pregnancy and lactation.

Gastrointestinal disorders: Constipation, diarrhoea, black stool, nausea, vomiting, gastrointestinal discomfort. Immune system disorders: Rarely, allergic reactions.

Ferrous fumarate: Fe chelates with tetracyclines, absorption of both agents may be impaired; it also chelates with acetohydroxamic acid, reducing the absorption of both. May reduce the absorption of penicillamine, fluoroquinolones, levodopa, carbidopa, entacapone, bisphosphonates, thyroid hormones (e.g. levothyroxine), mycophenolate, cefdinir, Zn, and eltrombopag. Reduced absorption with antacids and PPIs, neomycin, colestyramine, Ca, oral Mg salts and other mineral supplements, Zn and trientine. May form insoluble complexes with bicarbonates, carbonates, oxalates, or phosphates, thus absorption is impaired. Increased absorption with ascorbic or citric acid. Chloramphenicol delays plasma clearance and incorporation of Fe into RBC by interfering with erythropoiesis. May reduce the hypotensive effect of methyldopa. May form toxic complexes with dimercaprol. Increased risk of Fe overload with parenteral Fe. Folic acid: May reduce serum levels of anticonvulsants (e.g. phenobarbital, phenytoin, primidone). Decreased serum level with sulfasalazine. May diminish the therapeutic effect of raltitrexed.

Vitamins & Minerals (Pre & Post Natal) / Antianemics

V04CX02 - folic acid
B03AA02 - ferrous fumarate ; Belongs to the class of oral iron bivalent preparations. Used in the treatment of anemia.
B03BB01 - folic acid ; Belongs to the class of folic acid and derivatives. Used in the treatment of anemia.